ABSTRACT. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and. Abstract: Inositol hexaphosphate (IP6) is a naturally occur- ring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain. While IP-6 is found in rice bran and other foods, there are good reasons to take an IP-6 & Inositol supplement. First, IP-6 is getter absorbed in pure form without.

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Comparative toxicities of selected minor dietary non-nutrients with chemopreventive properties. IP 6 was also potent in inhibiting experimental hepatoma 31 However, cells from different origin have different sensitivity to IP 6 the leukemic cell lines seem to be highly susceptible to IP 6 inositok, suggesting that IP 6 may affect different cell types through different mechanisms of action.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Almost 15 y ago, Shamsuddin et al. The antiproliferative activity of IP 6 was further reported in human colon cancer HT cells 28estrogen receptor—positive and estrogen receptor—negative human breast cancer cells 32cervical cancer 25prostate cancer 153334 lp6, and HepG2 hepatoma cell lines Myo -inositol is a parent compound of IP 6. IP 6 can io6 modulate cellular response at the level of receptor binding. Inositol pentakis- and hexakisphosphate metabolism adds versatility to the actions of inositol polyphosphates: Adapted from Shamsuddin et al.

Antitumor activity of phytic acid inositol hexaphosphate in murine transplanted and metastatic fibrosarcoma, a pilot study. Recently IP 6 has received much attention pi6 its role in cancer prevention and control of experimental tumor growth, progression, and metastasis.

IP 6a natural compound with virtually no toxicity, can satisfy this special and very important requirement for cancer prevention. However, the effectiveness and safety of IP6 plus inositol at therapeutic doses needs to be determined in phase I and phase II clinical trials in humans. In this model experimental lung metastases are developed after intravenous injections of FSA-1 cells; intraperitoneal injections of IP 6 resulted in a significant reduction of metastatic lung colonies A striking anticancer action of IP 6 was demonstrated in different experimental models.


Protection against cancer by dietary IP6 and inositol.

Citing articles via Google Scholar. Exogenously administered IP6 is rapidly taken into the cells and dephosphorylated inostiol lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP6 holds great promise in our strategies for the prevention and treatment of cancer.

Contrary to the dogma and skepticism at that time, we showed that IP 6 is taken up by malignant cells 21 and that orally administered IP inosltol can reach target tumor tissue distant from the gastrointestinal tract In addition to being inositoo in plants, IP 6 is contained in almost all mammalian cells, although in much smaller amounts, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation.

We were able to obtain comparable or even stronger tumor inhibition with much lower concentrations of IP 6 when it was given in drinking water.

However, the effectiveness and safety of IP 6 plus inositol at iinositol doses needs to be determined in phase I and phase II clinical trials in humans.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

IP lp6after sterically blocking the heparin-binding domain of basic fibroblast growth factor, disrupted further receptor interactions IP 6 was further shown to increase differentiation of human colon carcinoma HT cells 2829prostate cancer cells ibositolbreast cancer cells 32and rhabdomyosarcoma cells Absorption and excretion of orally administered inositol hexaphosphate IP 6 or phytate in humans. The data strongly argue for the use of IP6 plus inositol in our strategies for cancer prevention and treatment.


Role of renin-angiotensin system antagonists in the prevention of bevacizumab and sunitinib mediated cardiac dysfunction. Rice bran treatment for patients with hypercalciuric stones: Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU This action is related to the IP 6 structure that is similar to Ddeoxyfluoro-PtdIns, an inhibitor of phosphatidylinositol-3 kinase A Randomized Controlled Trial. Antiproliferative effect inositol hexaphosphate IP 6 in breast cancer cells is mediated by increase in p27 and decrease in Rb protein phosphorylation.

Many potential beneficial actions of IP 6 have been described. However, recent studies demonstrate that this antinutrient effect of IP 6 can be manifested only when large quantities of IP 6 are consumed in combination with a diet poor in oligoelements 60 — Analyzing absorption, intracellular distribution, and metabolism of IP 6 in HT human colon carcinoma and cells of hematopoietic lineage K, human erythroleukemia and YAC-1, mouse lymphoma cellswe found inowitol IP lnositol is rapidly taken up by mechanisms probably involving pinocytosis or receptor-mediated endocytosis, transported intracellularly, and dephosphorylated into inositol phosphates with fewer phosphate groups Current cancer treatment recognizes the importance of using combination therapy to increase efficacy and decrease side effects of conventional chemotherapy.

Synergistic cancer inhibition by IP 6 when combined with inositol Ins 1,2-dimethylhydrazine DMH – lnositol colon carcinoma in mice.