Phenytoin Injection prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side. Page 1. Page 4. Malta ADR Reporting website: adrportal 5. How to store Epanutin RMP The storage of Epanutin RMP will not be . Epanutin Injection is used for Seizure, Migraine, Cardiac arrhythmias and other conditions. Epanutin Injection may also be used for purposes not listed in this.

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Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes and may reduce the levels of drugs metabolized by these enzymes. There is unjection higher incidence of this in black patients. There is a risk of potentially fatal respiratory or circulatory depression.

Subscribe to receive email notifications whenever new articles are published. When Pro-Epanutin is administered by IV infusion, maximum plasma fosphenytoin concentrations are achieved at the end of the infusion.


The solution should be injected slowly, intravenously and at a uniform rate which should not exceed 1 ml 50 mg per minute. Volume mL to draw up. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Diabetes Phenytoin may raise blood glucose in diabetic patients. Dizziness, motor twitchings, headache, paraesthesia somnolence, drowsiness and dysgeusia have also been observed.

In animal studies, fosphenytoin had no effect on fertility in male rats but decreased fertility in female rats see section 5. Click here for US version. Genetic toxicity studies showed that fosphenytoin was not mutagenic in bacteria or in mammalian cells in vitro. Find out more here. Pro-Epanutin is a clear, colourless to pale yellow, sterile solution buffered with trometamol adjusted to pH 8.


Please refer to Tables for examples of dosing, dilution, and infusion time calculations. Distribution Its volume of distribution has been estimated to be between 0. Other more serious and rare forms have included bullous, exfoliative or purpuric dermatitis, lupus erythematosus, Stevens-Johnson syndrome and toxic epidermal necrolysis see section 4.

Epanutin Ready Mixed Parenteral

After injection phenytoin is distributed into body fluids including the cerebrospinal fluid CSF. Parenteral phenytoin affects ventricular automaticity. The lethal inkection in children is not known.

The initial symptoms are nystagmus, ataxia and dysarthria. Phenytoin is not effective for absence petit mal seizures.

Hyperglycaemia has been reported. Each 10 mL vial contains mg PE.

Phenytoin Injection Dosage & Rx Info | Uses, Side Effects – MPR

The pharmacokinetics of phenytoin following IV administration of Pro-Epanutin, are complex and when used in an emergency setting e. Appropriate dose, dosing volume, number of vials of Pro-Epanutin, volume of diluent, and minimum infusion time should always be calculated for the patient’s exact body weight when not included in the examples.

See Table 6 for infusion times. Skin and subcutaneous tissue disorders. Patients and caregivers of patients should be advised to seek medical advice should signs of suicidal ideation or behaviour emerge. Increased cardiovascular risk associated with rapid infusion; monitor during and after therapy; rate reduction or discontinuation may be needed. It is also indicated for the treatment of life-threatening ventricular arrhythmias or arrhythmias secondary to digitalis intoxication, when these have not responded to other available antiarrhythmic treatments or when other antiarrhythmic agents cannot be used.


Bring a medicine box, container, or label with you to help doctors with necessary information. Fertility In animal studies, phenytoin had no direct effect on fertility. MedDRA System organ class. Peak concentrations occur at approximately 30 minutes postdose. Haematopoietic complications, some fatal, have occasionally been reported in association with administration of phenytoin.

Formate and phosphate are metabolites of fosphenytoin and therefore, may contribute to signs of toxicity following overdosage. Active ingredient phenytoin sodium. Investigations Not Known Thyroid function test abnormal. The risk of serious skin reactions and other hypersensitivity reactions to phenytoin may be higher in black patients. Foetal toxicity, developmental toxicity and teratogenicity occurred in offspring from rats given fosphenytoin prior to and during mating, gestation, and lactation.

The fraction of unbound phenytoin is increased in patients with renal or hepatic disease, or in those with hypoalbuminaemia. Soft tissue irritation may vary from slight tenderness to extensive necrosis, sloughing and in rare instances has led to amputation.

Herbal preparations containing St. What other medicines does Epanutin Injection interact with? Fosphenytoin is a pro-drug of phenytoin and it is rapidly converted into phenytoin mole for mole.

Reporting of side effects If you dpanutin any side effects, talk to your doctor, pharmacist or nurse.